At Harry's, they recommend a Thomas H. Handy rye on the rocks and understand that this is a bar where one can tend to the serious business of drinking:
It's a busy place, unpretentious but not divey (for that, tell your cabdriver to take you to Davey's Uptown Ramblers Club at 3402 Main Street), with good food (the usual stuff, with a Mexican bent), hand-burned country CDs on the jukebox, an ungodly number of whiskeys, and bartenders who can explain what's in every bottle.
As for Manifesto, Esquire points you to a Jackson Co. Democratic Club cocktail (rye, luxardo, yellow chartreuse, lemon, and orange bitters) and discovers that even a speakeasy can't escape our Midwestern hospitality:
For a place with all the modern cocktail-bar trappings - back-alley entrance, basement digs, posted rules of deportment, drinks with abundant house-made trimmings, and lots of sherry, mezcal, and obscure Italian amari - Manifesto isn't a place that makes drinkers feel trapped by its trappings. It's lively. Jolly, even. (The entrance is around back in the alley; reservations are recommended.)
Whether you agree or disagree, I suggest you have this debate over a cocktail of your own.